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MTHF + B12 is the most biologically active form of the water-soluble B vitamin, folate. It is the preferred form of folate supplementation due to an array of conditions that can limit conversion or absorption of folic acid. Data indicate that supplementing with 5-MTHF increases plasma folate more effectively than folic acid. MecobalActiveTM, which is found in the MTHF + B12 formula, is a highly pure form of methylcobalamin that does not use any harmful solvents during manufacture.*